Synthesis and in-vitro Cytotoxic Screening of Some Novel 3, 4-diphenyl-2, 5-diaza-bicyclo [4.3.1] Decane Derivatives
نویسندگان
چکیده
The bicyclo compounds possess a wide variety of activities so, in the present study we have develop a novel and simple method for the synthesis of such 3, 4-diphenyl-2, 5-diaza-bicyclo [4.3.1] decane derivatives. All the compounds synthesized were characterized by running TLC, IR, NMR and LCMS spectra. All the title compounds were screened for the determination of Cytotoxicity by MTT and SRB assay methods on Vero cell line (African green monkey kidney normal cell line). The compound D and compound C showed potent cytotoxicity as compared to compound E, compound A and compound B in both the assay performed.
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